If you have recurrent mouth ulcers (ulcers that keep coming back), your GP may ask you a series of questions to help determine whether your mouth ulcers have an underlying cause. For example, they may ask you about: Remember, not all mouth ulcers are aphthous ulcers. Other types of ulcer can occur in the mouth and mouth ulcers can be a sign of an underlying illness or disease. Important : cancer of the mouth can sometimes start as an unusual mouth ulcer that does not heal. Everyday Pain Relief: Ulcers. Many familiar over-the-counter pain relief drugs can cause harmful side effects for those with ulcers. Here's what you need to know. Summary. Mouth ulcers is found among people who take Ibuprofen, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Zometa, and have Rheumatoid arthritis. Mouth ulcers are common and should clear up on their own within a week or two. They're rarely a sign of anything serious but may be uncomfortable to live with. Ibuprofen is an anti-inflammatory and fever-reducing medication. It can be used to treat pain and inflammation associated with many conditions such as menstrual cramps, headaches, arthritis, muscle pain,and toothaches. Mouth ulcers are aggravating at best and may be extremely painful. Also called canker sores or aphthous ulcers, mouth ulcers can be triggered by various factors, including stress, illness, or simply biting your cheek. The risk of major GI issues with Ibuprofen is approximately 16%. Doctors give unbiased, trusted information on whether Advil can cause or treat Mouth Ulcers: Dr. Vallury on can ibuprofen cause mouth ulcers: All NSAIDs can cause ulcers. The risk of major GI issues with Ibuprofen is approximately 16%. Mouth ulcers need time to heal and there is no quick fix. Avoiding things that irritate your mouth ulcer should help: Although most mouth ulcers are harmless, a long-lasting mouth ulcer is sometimes a sign of mouth cancer. It's best to get it checked. You may have more than one ulcer at a time and.